Charles Darwin "had medicine in his blood" (Bynum 1983). His father and grandfather were physicians, and he himself studied medicine. Although Darwin left medical school after two years and did not become a physician, he retained a strong interest in medicine and regularly used examples drawn from human biology and medicine in his writings. Clearly, he believed that medicine fell within the purview of his theory of evolution, and he recognized the ways in which the study of evolution and of (...) medicine could be mutually enriching. In The Descent of Man (1871), Darwin argued that humans, like other species, have evolved from earlier, ancestral species. "Descent with modification," Darwin's term for evolution, accounts .. (shrink)

Morton Arnsdorf, the book review editor of Perspectives in Biology and Medicine, was tragically killed in an automobile accident on June 9, 2010. Mort grew up in Chicago, went to college at Harvard, and then to medical school at the Columbia University College of Physicians and Surgeons. In college, Mort majored in History of Science, and he retained strong interests in history throughout his medical career. Mort did a residency in medicine at the University of Chicago, went back to Columbia (...) for fellowship training, and then joined the faculty of the University of Chicago in 1973. During his tenure in Chicago, he became Professor of Medicine and served both as Chief of the Section of Cardiology and as .. (shrink)

Richard Landau, the longtime editor of Perspectives in Biology and Medicine, died on November 3, 2015. Richard grew up in St. Louis. Like many people of his generation, he was inspired to become a physician by Paul de Kruif ’s book Microbe Hunters. Richard went to college and medical school at Washington University in St. Louis and came to the University of Chicago in 1940 as a resident in medicine. Except for a two-year stint in the army during World War (...) II, he spent the rest of his career at the university, rising through the academic ranks to become Professor of Medicine in 1959. Richard held several important administrative positions at the university; he served as Chief of the Section of Endocrinology.. (shrink)

Although natural selection might be expected to reduce the incidence and severity of disease, disease persists. Natural selection leads to increases in the mean fitness of populations and so will reduce the frequency of disease-associated alleles, but other evolutionary processes, such as mutation and gene flow, may introduce or increase the frequency of these deleterious alleles. The pleiotropic actions of genes and the epistatic interactions between them complicate the relationship between genotype and phenotype, and may result in the preservation of (...) disease-associated alleles. Deleterious alleles may also be maintained because of linkage to beneficial alleles. The inability of natural selection to eliminate diseases of aging is a reminder that fitness – success in producing progeny, or in contributing genes to the population gene pool – is not equivalent to the absence of disease. Nutritional or psychosocial cues may lead to life history strategies that maximize survival to reproductive maturity at the expense of disease later in life. Natural selection acts on genes, cells, and groups, as well as on organisms; the outcome of evolution reflects selection at different levels of biological organization. Finally, the human environment is constantly changing, largely because of the evolution of our parasites and because of changes in cultural beliefs and practices; genetic evolution is comparatively slow and lags behind environmental change. An evolutionary nosology complements traditional medical nosologies and enhances our understanding of the persistence of disease and the meaning of human variation. (shrink)